![]() ![]() In adult humans, it is found throughout the cerebellum and forebrain it is also found in the testes. It is found in the dorsal telencephalon in fetuses. HAR1A is active in the developing human brain between the 7th and 18th gestational weeks. ![]() The RNA structure of HAR1A has been shown to be stable, with a secondary structure unlike those previously described. Two RNA genes, HAR1F and HAR1R, were identified partly within the region. One particularly altered region, HAR1, was found in a stretch of genome with no known protein-coding RNA sequences. Many of the HARs are associated with genes known to play a role in neurodevelopment. These 49 regions represent parts of the human genome that differ significantly from highly conserved regions of our closest ancestors in terms of evolution. HAR1A was identified in August 2006 when human accelerated regions (HARs) were first investigated. ![]() HAR1A is expressed in Cajal-Retzius cells, contemporaneously with the protein reelin.
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